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Topimax (Topiramate)

Topimax is an anticonvulsant medication used in the treatment of epilepsy and migraine headaches. Topimax is also commonly used off-label to treat a wide range of mood disorders, eating disorders, and to aid in substance abuse therapy. While Topimax's mechanism of action is unclear, we know that the drug blocks sodium channels in the body that deliver electrical impulses to excitable cells (such as nerve, muscle, and brain cells). By doing so, Topimax appears to enhance the activity of a chemical messenger (neurotransmitter) known as gamma-aminobutyric acid (GABA).

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Topimax is used alone or with other medications to treat certain types of seizures including primary generalized tonic-clonic seizures (formerly known as a grand mal seizure; seizure that involves the entire body) and partial onset seizures (seizures that involve only one part of the brain). Topimax is also used with other medications to control seizures in people who have Lennox-Gastaut syndrome (a disorder that causes seizures and developmental delays). Topimax is also used to prevent migraine headaches but not to relieve the pain of migraine headaches when they occur. Topimax is in a class of medications called anticonvulsants. It works by decreasing abnormal excitement in the brain.

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Canonical Wnt pathway is crucial in diverse biological processes and mediates the progression and regression of liver fibrosis. Diabetic hyperglycemia was induced in male selectively bred DIO rats by a single low dose (30mg/kg) injection of STZ. Immunological characterization of blood group A reactive protectins from Helix pomatia. In recent years the C57BL/6J mouse has gained popularity as a model for studying the genetics of diet-induced atherosclerosis.

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These data show an unusual induction of naive CD8 T cells contributed to the lower frequency of Ag-specific CTLs observed after immunization in the liver, suggesting that limited priming in liver compared with peripheral tissues is responsible for this outcome. The water contact angle decreased from 73 degrees on a pristine PMMA surface to 37.5 degrees on a PVA-coated surface, indicating that the PVA coating increased hydrophilicity.

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Solid-phase synthesis of oligonucleotides on an insoluble, macroporous carrier SAF measurement with an autofluorescence reader is a non-invasive way to assess the risk of DR.

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The majority (89 percent) of providers in this sample treat chronic pain patients, and more than half (54 percent) have frequent concerns about addiction, tolerance, and diversion. We provide direct comparison of EThcD with ETD and HCD for DiLeu- and TMT-labeled HEK cell lysate and IMAC enriched phosphopeptides. Values for whales were down to half the length (i.e., 1.1, 3, and 5 million generations), perhaps due to the reduced mechanical constraints of living in an aquatic environment. This study was carried out to determine the prevalence of CM in newborns of mothers co-infected with HIV and malaria compared to HIV-negative mothers with malaria in Benin-City.

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After the behavioral response we see correlates in areas often associated with the default-mode network and introspective processing, including precuneus, angular gyri, and posterior cingulate cortex. Using a randomized, double-blind, cross-over design, 10 exercise-trained, non-diabetic men reported to the lab in a 10 hour fasted state, on two different mornings separated by 1-2 weeks, and were subjected to an OGTT by ingesting a 75 gram dextrose solution.

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Carcasses had been frozen at an undetermined temperature below 0 C for an initial 14 days and then at -21 to -24 for 100-159 days. We conclude that mAbs ICR9 and ICR10 are ideal tools for investigating the expression patterns of wild-type EGFR protein in tumour specimens using immunohistochemistry, and to determine their prognostic significance, as well as predictive value for response to therapy with EGFR antibodies.

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Denudation of human amniotic membrane by a novel process and its characterisations for biomedical applications. Specific interactions between lipids and membrane proteins have been observed in recent high-resolution crystal structures of membrane proteins.

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Drug solution in phosphate buffered saline (PBS) was perfused through a ingle-pass intestinal perfusion (SPIP) with flow rate of 0.21 ml/min and samples were taken from outlet tubing at different time points up to 90 min. Perspectives on organ and tissue donation among Chinese Canadians. Infection is a common complication of pelvic resection for bone tumors. As a compensation of cardiac energy supply, FFAs are released through the hydrolysis of very low density lipoprotein (VLDL) and chylomicrons (CM) due to activation of LPL activity.

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Southern blot analysis of restriction endonuclease-digested genomic DNA, indicated that aox1 is a single, nuclear-encoded gene in S. A number of these compounds proved to be active against Trypanosoma brucei. Interleukin-15 and cisplatin co-encapsulated thermosensitive polypeptide hydrogels for combined immuno-chemotherapy. Expression of members of the trk family in the developing postnatal rat brain.

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To compare the health-related quality of life (HRQL) indicators between institutionalized and community-dwelling elderly men and women. It was found that the optimal efficiency for the IL columns is attained at lower carrier gas velocities in comparison with traditional phases. The objective of this study was to assess the nutritional and microbiological quality of commercial enteral and homemade blenderized whole foods diets intended to adult patients in home nutritional therapy.

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We describe our experience with nine patients with head and neck pain of malignant origin who were treated with continuous low-dose intrathecal morphine via a lumbar catheter and implantable subcutaneous drug delivery pump. Regression of IL-1-producing transformed fibroblasts was strongly reduced but not completely abolished in sublethally irradiated mice.

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Stabilization of actin by phalloidin: a differential scanning calorimetric study. Comparative Transcriptomic Analysis of Virulence Factors in Leptosphaeria maculans during Compatible and Incompatible Interactions with Canola. The importance of including people with dementia in research and the possible benefits to them of taking part are discussed and the issues are linked to practice through examples of my own research with people with dementia. To review our current understanding of immunotherapy, the immune mechanisms underlying food allergy, and the methodological advances that are furthering our understanding of the role of immune cells and other molecules in mediating food allergies. The results also found that males, older students and those studying Engineering and the Social and Human Sciences are those reporting higher levels of environmental knowledge.

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Miniature isotropic optical fibre probes for quantitative light dosimetry in tissue. PON1 genotypes were studied using PCR and restriction fragment length polymorphism analysis. National consensus conference on gerontologic nursing competencies. Oxidized low density lipoproteins exert arrhythmogenic effects in rabbit Purkinje fibers.

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Implantation of morphine pellets (400mg) in female guinea pigs did depress CCK-induced emptying of gallbladder bile. Altogether, this shows TgATG9 is important for the fate of Toxoplasma in immune cells and contributes to the overall virulence of the parasite, possibly through an involvement in a canonical autophagy pathway. Students used technology, such as computer-generated virtual patients and iPads, during the PBL sessions. Osteoid osteoma of the talus: a rare cause for pain in the ankle joint Instead, brain amino acid pools under in vivo steady-state conditions appear to be primarily regulated by the rate of amino acid utilization by the peripheral tissues.

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The TVF abduction angles during cough can be reliably measured from laryngeal videoendoscopy in young healthy individuals. The clinical and radiological findings in a patient with long-standing ankylosing spondylitis who developed the clinical features of a cauda equina syndrome are presented. Various infection status and molecular evidence for horizontal transmission and recombination of Wolbachia and Cardinium among rice planthoppers and related species. ProstaCaid inhibits tumor growth in a xenograft model of human prostate cancer. Postoperative urinary tract infections--with special reference to prevention of iatrogenic urinary tract infection

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System design of a computer based library circulation system for the radiology file room. Co-exposure to melamine and cyanuric acid in livestock, fish, pets and laboratory animals shows higher toxicity compared with melamine or cyanuric acid alone. Combinations of targeted drugs could theoretically achieve better inhibition of a given pathway, inhibition of different pathways, or inhibition of a pathway involved in the resistance to a given drug. Computers should play an important role in mammography screening.

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The combination of diabetes and depression is relevant for medical care because of its health burden. Hirayama disease (HD) is a rare motor disorder mainly affecting young men, characterized by atrophy and weakness of forearm and hand muscles corresponding to a C7-T1 myotome distribution.

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Question 20: What are the regulatory mechanisms occurring in donor cells that determine selective sorting of biological content into vesicles and their biological consequences in recipient cells? The sixth patient required surgery one month after endoscopic treatment of the acute biliary obstruction.

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A trinuclear defect-grid iron(II) spin crossover complex with a large hysteresis loop that is readily silenced by solvent vapor. Morbid obesity is increasing in prevalence among patients undergoing PCI and is associated with a higher risk of mortality and morbidity. Assessment of knowledge and skills about growth monitoring amongst child development project officers.

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Clinical syndromes associated with DNA repair deficiency and enhanced sun sensitivity. A custom acrylic jig with 2 rows of platinum needle electrodes was used to bend ears at the middle of the pinna and to perform EMR.

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Number of cyclic loadings survived, stiffness, yield load, maximum load, and graft elongation, as well as failure mode, were analyzed after ACL reconstruction with 5- to 9-mm soft-tissue grafts. The evidences point to attempts of replacing the traditional content transmission notion, without however, effectively showing another pedagogical tendency.

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The enhanced PEC performance is ascribed to improved light absorption induced by the plasmonic effect, trapped electrons of Au NPs, and cascade band alignment of the shell material and ZnO. This involves the use of a large fragment Herbert Screw that is entirely embedded within the bone. Characterization and hormonal regulation of estrogen binding proteins in the MTW-9B transplantable rat mammary tumor.

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This was a retrospective case-control study of patients with CDAD at Yeungnam University Medical Center, seen from January 2004 to December 2008. Histochemical changes of carbohydrate and protein contents in the digestive gland cells of the land snail Monacha cartusiana following starvation. Suicidal children younger than 12 years are often clinically different from suicidal adolescents and adults and may require unique assessment and disposition strategies in the ED.

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In vitro platelet release by rat megakaryocytes: effect of heterologous antiplatelet serum. By creating a chorioretinal adhesion in areas of potential retinal break formation, laser photocoagulation may be an effective prophylaxis against retinal detachment in ARN. Lipid peroxidation and antioxidant system functions in staphylococcal sepsis in nursing infants and the principles of pathogenetic therapy

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The 3D characterization of bridge structures between domains over the background and breaks within domains on guiding lines sheds light on possible origins of common DSA defects. The magnitude and directionality of this association differed by indicator, underscoring the need for further investigation into the relationship between standard deviation and design effect. Metabolic fingerprinting of high-fat plasma samples processed by centrifugation- and filtration-based protein precipitation delineates significant differences in metabolite information coverage. Cisplatin/etoposide is a highly active regimen in metastatic breast cancer, but cisplatin dose-escalation is limited by nonhematologic toxicity. Aminoaldehyde dehydrogenase activity during wound healing of mechanically injured pea seedlings.

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All contained metalloproteinases in the range 60-120 kDa, with neutral/alkaline pH optima. Investigation on the association between IL-10 C819T gene polymorphisms and susceptibility to gastric cancer. Decreased activation was greater in extent for words than for pictures.

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Using structural analysis, molecular dynamics, and biochemistry, we show that TA increases intramolecular contacts within the LBD to drive affinity and enhance stability of the receptor-ligand complex. Fifty-six Acanthamoeba isolates from 56 patients with clinically proven AK were studied. A total number of 44 international medical school students from diverse background were enrolled in this study, and randomly divided into two groups. An alternative direct technique for the fabrication of an implant-supported, screw-retained fixed interim restoration. Better molecular and genetic biomarkers are acutely needed to help identify those at risk of liver injury particularly for those needing antituberculosis therapy.

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The abundance of processed pseudogenes in different vertebrate species is known to be proportional to the length of their oogenesis. Physical deconditioning may explain the elevation of resting HR in patients with RA. Besides, in this work, we introduce a novel architecture to accelerate this algebraic derivative estimator using reconfigurable logic.

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Here, we describe a method for decreasing protein complexity in plasma samples within a narrow pH range by depleting high-abundance plasma proteins. A review of the genus Paraleptomenes Giordani Soika, 1970 (Hymenoptera: Vespidae: Eumeninae: Odynerini) from the Indian subcontinent,with the description of a new species from the eastern Himalayas. A low technology emanator treated with the volatile pyrethroid transfluthrin confers long term protection against outdoor biting vectors of lymphatic filariasis, arboviruses and malaria. Lifestyle behaviors are the largest contributors to health status. Due to lower rates of morbidity and mortality, an endovascular approach was chosen instead of open surgical repair.

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Effectiveness of treatment is, however, highly variable and unpredictable. Mononuclear blood cell magnesium in older subjects: evaluation of its use in clinical practice.

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Here, we summarize the evidence for GALT as a site of residual HIV replication, highlight the consequences of persistent infection in tissues, identify current pharmacologic knowledge of drug exposure in GALT, define the challenges that hinder eradication from this site, and propose several avenues for pharmacologic intervention. Diazoxide, with or without either K(ATP)-channel blocker, attenuated the significant myocyte swelling and reduced contractility secondary to metabolic inhibition.

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The CGC/CGC diplotype of ABCB1 polymorphisms was associated with variability in cold pain threshold and pain tolerance in healthy males. Thirty-five diabetes prone BB rats of both sexes were divided into two groups: experimental animals were exposed to multiple, concurrent, and unpredictable environmental stressors, while littermate controls were exposed to a standard lab environment.

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Failure of catecholamine development following unilateral diencephalic lesions in the neonatal rat. A Data Fusion Approach to Enhance Association Study in Epilepsy. ETOH intoxication is an independent predictor for mortality in patients with severe TBI patients and is associated with higher complication rates.

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Nitric oxide synthase 3 (NOS3) gene polymorphisms are said to be associated with CRC risk but the conclusion is still controversial. Conformational transitions inside micelles, followed by aggregation of micelles and their stabilization as they relate to the metastable structure of silk are described. Two Cases are described of spontaneous vascular closure occuring in eyes with arteriovenous malformations, causing visual loss due to retinal ischaemia and rubcosis iridis. The structure activity relationships (SARs) and anticancer mechanisms of aporphinoid alkaloids, as well as simple aporphine, oxoaporphine, dehydroaporphine and dimeric aporphine, have been summarized. This binding is dependent on the presence of predominant motif arrangements in the peptides which are likely to correspond to specific subsites within the class I binding cleft.

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The aspects most needing attention were: dental, speech therapy and local healthcare service. Using an established, biophysically informed model of a competitive attractor network for decision making, we found that decaying tail activity from the previous trial caused choice hysteresis, especially during difficult trials, and accurately predicted human perceptual choices.

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Additional protocols describe optimization of the method to increase the yield of specific proteins, adaptation of the method for downstream applications such as affinity purification, and preparation of the cytoplasmic (S-100) fraction. Accuracy of the medication history at admission to hospital in clarithromycin dose for community acquired pneumonia case Saudi Arabia. Injury, disability and access to care in Rwanda: results of a nationwide cross-sectional population study.

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In Tx-3 mice levels of thymosin alpha 1 (TSN alpha 1), a potent thymic hormone involved in the development of helper T cells, was previously shown to be high after 7 days. Our two outstanding medical problems are being neglected largely because of the lack norvir 100 mg prix de west of funds to support both the long-term research and the raising of old animals needed for adequate investigation in this field. Risk factors for the development of RVF after LVAD have been described, and may identify a population best managed with biventricular support. This retrospective study was approved by the institutional review board, and written informed consent for the CT examination was obtained. Rome criteria were formulated to define functional gastrointestinal disorders (Rome III criteria, 2006) excluding organic diagnoses when alarm symptoms were absent.

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Epidemiologic, clinical, laboratory, and treatment data were collected from 39 different collaborative hospitals throughout France. Ossifying fibromyxoid tumour (OFT) is a recently described, mesenchymal neoplasm originally defined as a borderline or low-grade malignant lesion. FGR was performed in 18 clinics in Germany (ALA-Glioma Study Group, participants see end of paper) amotaks dis angina treatment in a phase III trial comprising an ALA group and a white-light group.

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Global warming is expected to increase the occurrence, distribution, and intensity of avian malaria across this elevational gradient and threaten high-elevation refugia, which is the key to survival of many susceptible Hawaiian birds. This paper presents riomet manufacturer coupons a review of the current knowledge regarding the macro- and micronutrient requirements of infants and discusses issues related to these requirements during the first year of life. Who might benefit from early aspirin after coronary artery surgery? These were studied in routine hematoxylin-and-eosin-stained sections and with immunohistochemical stains to characterize the inflammatory infiltrate.

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An equation to predict maximum acceptable loads for repetitive tasks based on duty cycle: evaluation with lifting and lowering tasks. Surgery bpac antibiotics pregnancy augmentin was not required as the paraplegia gradually improved until, within 1 hour, it had completely resolved.